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KMID : 1130620210170040541
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Journal of Clinical Neurology
2021 Volume.17 No. 4 p.541 ~ p.545
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Miller Fisher Syndrome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Systematic Review
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Martins-Filho Paulo Ricardo
de Andrade Ana Luiza Pereira
de Andrade Ana Julia Pereira
da Silva Maria Daniella Moura
de Souza Araujo Adriano Antunes
Nunes Paula Santos
Santos Victor Santana
Ferreira Lis Campos
de Aquino Neves Eduardo Luis
Quintans-Junior Lucindo Jose
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Abstract
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Background and Purpose: Miller Fisher syndrome (MFS) is a subtype of Guillain-Barre syndrome characterized by the triad of ophthalmoparesis, areflexia, and ataxia. Although cases of MFS have been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, no studies have synthesized the clinical characteristics of patients with this condition.
Methods: In this rapid systematic review, we searched the PubMed database to identify studies on MFS associated with SARS-CoV-2 infection.
Results: This review identified 11 cases, of whom 3 were hospitalized with motor and/or sensory polyneuropathy as the first sign of SARS-CoV-2 infection. SARS-CoV-2 RNA was not detected in analyses of cerebrospinal fluid, suggesting a mechanism of immune-mediated injury rather than direct viral neurotropism. However, antiganglioside antibodies were found in only two of the nine patients tested. It is possible that target antigens other than gangliosides are involved in MFS associated with SARS-CoV-2 infection.
Conclusions: The present patients exhibited clinical improvement after being treated with intravenous immunoglobulin. Although rare, patients with SARS-CoV-2 infection may present neurological symptoms suggestive of MFS. Early recognition of the MFS clinical triad is essential for the timely initiation of treatment.
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KEYWORD
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coronavirus disease 2019, severe acute respiratory syndrome coronavirus 2, Guillain-Barre syndrome, Miller Fisher syndrome
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